Mixed Antigens

Reading The Red Queen: Sex and the Evolution of Human Nature, it made me happier that I am probably more disease resistant than my peers due to having very different antigens due to my mixed heritage. One of my hopes was that more mixed kids would be born making society healthier.

This helped me realize though that benefit comes with a dark side. Very different antigen combinations make it more difficult to match bone marrow. From the Mixed Marrow mission,

Race holds a critical role in finding a marrow match. Genetic makeup must be similar between the donor and the recipient in order for a match to occur. For mixed patients, their monoracial parents and relatives will not likely match them and siblings only hold about a 1 in 4 chance. Not only is ethnicity a factor, but the probability of which antigens are passed down from each parent makes finding a match that much harder. Finding a marrow match has been compared at times as having the odds of “finding a needle in a haystack” or “winning the lottery.”

Guess I was lucky never to need a transplant.